The Wellington Guelph Drug Strategy is a coalition of 30 partner agencies and members of the lived experience community, who are working to implement a 4-Pillars drug strategy in the municipalities of Wellington County and the City of Guelph. The 4-Pillars include Prevention, Treatment, Enforcement and Harm Reduction, with a 4-Pillars strategy recognizing that no one sector can effectively respond to substance misuse in isolation. Our cross-sectoral partnerships acknowledge the integral role that each pillar plays, and in many instances, weave the pillars together in our strategies and responses. In doing so, we have made many successful strides towards our goal of reducing the impacts of substance misuse in our communities.